Negative regulation of protein-containing complex assembly

Across TCGA patient cohorts, RNA activity of the Negative regulation of protein-containing complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC01558, CHRM1, and RNU6-681P, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein-containing complex assembly activity versus LINC01558 in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC01558 →	+0.690	+0.663	<.001	.007	3	1
BRCA	CHRM1 →	+1.470	+0.680	.007	.007	3	1
BRCA	RNU6-681P →	+1.050	+0.486	.002	.005	3	1
BRCA	COL5A1-AS1 →	+0.260	+0.486	.004	.005	3	1
BRCA	PPP1R9A-AS1 →	+0.040	+0.486	.002	.005	3	1
BRCA	RN7SL430P →	+0.446	+0.486	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031333 vs LINC01558 — BRCA

Explore this scatter interactively →