Negative regulation of protein-containing complex assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein-containing complex assembly pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR1, ACTB, and TCEAL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein-containing complex assembly activity versus WDR1 in LIVER (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	WDR1 →	+1.456	+0.178	.007	.004	3	6
BLOOD_Leukemia	ACTB →	+0.643	+0.132	<.001	.002	3	5
URINARY_TRACT	TCEAL1 →	+1.631	+0.344	<.001	<.001	3	5
OVARY	GNAI2 →	+0.865	+0.168	<.001	.005	3	5
LUNG_NSCLC_LUSC	RAB8B →	+2.727	+0.260	.005	.007	3	5
OVARY	FAM114A1 →	+1.041	+0.177	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031333 vs WDR1 — LIVER

Explore this scatter interactively →