Negative regulation of protein-containing complex assembly

Across TCGA cell cohorts, RNA activity of the Negative regulation of protein-containing complex assembly pathway is significantly associated with the protein abundance of multiple proteins, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN1, SH3GLB1, and SEPTIN7, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of protein-containing complex assembly activity versus TLN1 in PANCREAS (Pearson r = 0.65).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TLN1 →	+1.692	+0.161	<.001	<.001	3	13
OVARY	SH3GLB1 →	+1.231	+0.207	<.001	<.001	3	13
URINARY_TRACT	SEPTIN7 →	+1.375	+0.330	.002	.007	3	13
SKIN	NOP56 →	-0.843	-0.179	<.001	<.001	3	13
URINARY_TRACT	TUBB →	+2.104	+0.318	.002	<.001	3	13
URINARY_TRACT	ACTR2 →	+1.395	+0.344	.001	.006	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031333 vs TLN1 — PANCREAS

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