Lymphocyte costimulation

Across TCGA patient cohorts, RNA activity of the Lymphocyte costimulation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S351, and RGS19, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte costimulation activity versus RCSD1 in LSCC (Pearson r = 0.74).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCSD1 →	+0.662	+0.114	<.001	<.001	3	10
LSCC	RCSD1_S351 →	+0.723	+0.096	<.001	<.001	3	10
BRCA	RGS19 →	+0.468	+0.059	<.001	<.001	3	10
OV	RIN3 →	+0.477	+0.049	<.001	<.001	3	10
HNSC	SAMHD1 →	+0.654	+0.102	<.001	<.001	3	10
LSCC	SAMSN1_S23 →	+0.930	+0.105	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031294 vs RCSD1 — LSCC

Explore this scatter interactively →