Lymphocyte costimulation

Across TCGA patient cohorts, RNA activity of the Lymphocyte costimulation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGAP9, DOCK2, and SIGLEC10, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte costimulation activity versus ARHGAP9 in BRCA (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARHGAP9 →	+0.960	+0.604	<.001	<.001	3	9
HNSC	DOCK2 →	+1.131	+0.367	<.001	.001	3	8
HNSC	SIGLEC10 →	+1.051	+0.358	<.001	.001	3	8
HNSC	CD53 →	+1.387	+0.442	<.001	<.001	3	8
HNSC	C1QC →	+1.396	+0.352	<.001	.003	3	8
HNSC	SCIMP →	+0.797	+0.417	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031294 vs ARHGAP9 — BRCA

Explore this scatter interactively →