Lymphocyte costimulation

Across TCGA cell cohorts, RNA activity of the Lymphocyte costimulation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALS2CL, SPATA2, and ASAH1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALS2CL grouped by Lymphocyte costimulation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ALS2CL →	+2.488	+1.222	<.001	.002	3	4
STOMACH	SPATA2 →	-0.801	-0.249	.005	.005	3	4
LUNG_NSCLC_LUSC	ASAH1 →	+0.999	+0.133	.008	.006	3	3
PANCREAS	RB1CC1 →	+0.854	+0.313	<.001	<.001	3	3
OESOPHAGUS	KIT →	-0.905	-0.788	.005	.002	3	3
OESOPHAGUS	S100A3 →	-1.386	-1.069	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALS2CL by Lymphocyte costimulation activity — OESOPHAGUS

Explore this box plot interactively →