Lymphocyte costimulation

Across TCGA cell cohorts, RNA activity of the Lymphocyte costimulation pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRAT2, GLIPR1, and OAF, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lymphocyte costimulation activity versus FRAT2 in STOMACH (Pearson r = -0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	FRAT2 →	-1.260	-1.627	<.001	<.001	3	8
LUNG_NSCLC_LUSC	GLIPR1 →	+4.132	+1.822	.001	<.001	3	6
LUNG_NSCLC_LUSC	OAF →	+1.605	+1.194	.009	.007	3	6
LUNG_SCLC	EHD1 →	+0.910	+1.031	.006	<.001	3	5
SOFT_TISSUE	CAV2 →	+3.545	+1.254	.001	.004	3	5
SOFT_TISSUE	ANTXR2 →	+4.584	+1.581	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031294 vs FRAT2 — STOMACH

Explore this scatter interactively →