Membrane protein intracellular domain proteolysis

Across TCGA patient cohorts, RNA activity of the Membrane protein intracellular domain proteolysis pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_S368, VIM_S72, and VIM_S22, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane protein intracellular domain proteolysis activity versus RFC1_S368 in COAD (Pearson r = -0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RFC1_S368 →	-0.653	-0.051	<.001	<.001	3	6
GBM	VIM_S72 →	+0.578	+0.045	.002	.004	3	6
BRCA	VIM_S22 →	+0.457	+0.039	.004	<.001	3	6
BRCA	CLPX →	-0.190	-0.032	.003	.003	3	6
COAD	WDHD1 →	-0.536	-0.049	<.001	.004	3	6
BRCA	PRKG1 →	+0.360	+0.035	.003	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031293 vs RFC1_S368 — COAD

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