Membrane protein intracellular domain proteolysis

Across TCGA patient cohorts, RNA activity of the Membrane protein intracellular domain proteolysis pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUSD3, RPS7P12, and IGKV2D-29, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Membrane protein intracellular domain proteolysis activity versus SUSD3 in PDAC (Pearson r = -0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SUSD3 →	-0.378	-0.147	.004	.008	3	3
PDAC	RPS7P12 →	-0.199	-0.161	.006	.005	3	3
LUAD	IGKV2D-29 →	-1.444	-0.227	.004	.004	3	3
OV	NRG1 →	-0.400	-0.285	<.001	.006	3	2
OV	ALKAL1 →	-0.638	-0.308	.008	.003	3	2
HNSC	WDR83 →	-0.345	-0.196	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031293 vs SUSD3 — PDAC

Explore this scatter interactively →