Membrane protein intracellular domain proteolysis

Across TCGA cell cohorts, RNA activity of the Membrane protein intracellular domain proteolysis pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COX11, HSD17B10, and PAF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, COX11 grouped by Membrane protein intracellular domain proteolysis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COX11 →	-0.171	-0.083	.004	.009	3	5
LIVER	HSD17B10 →	-0.371	-0.150	.005	.007	3	5
BREAST	PAF1 →	-0.327	-0.073	.003	.001	2	6
SKIN	S100A2 →	-0.157	-0.107	.004	.001	3	4
LUNG_NSCLC_LUAD	GCLM →	-0.107	-0.112	.006	.005	3	4
LUNG_SCLC	SSX1 →	+0.119	+0.116	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

COX11 by Membrane protein intracellular domain proteolysis activity — LARGE_INTESTINE

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