GO:0031282Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts
Across TCGA patient cohorts, RNA activity of the Regulation of guanylate cyclase activity pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.
The most reproducible pathway-associated proteins across cancer lineages are SURF6_S138, CAVIN1, and EHD2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.
Each partner is linked to its corresponding Q-omics profile.
Pathway-associated proteins by consensus
Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.