GO:0031282Cross-omicsSHRNA → SHRNACellPairwise association · TCGA cohorts
Across TCGA cell cohorts, RNA activity of the Regulation of guanylate cyclase activity pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.
The most reproducible pathway-associated genes across cancer lineages are GUCA1A, NOS2, and ATP6V0B, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.
Each partner is linked to its corresponding Q-omics profile.
Pathway-associated genes by consensus
Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.