Positive regulation of cyclase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of cyclase activity pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYCR1, HSFX1, and ISL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of cyclase activity activity versus PYCR1 in STOMACH (Pearson r = -0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PYCR1 →	-1.322	-0.309	<.001	<.001	3	6
OESOPHAGUS	HSFX1 →	+0.682	+0.326	.002	.001	3	5
BLOOD_Myeloma	ISL2 →	-1.800	-0.356	.003	.001	3	5
LUNG_SCLC	RPS12 →	-0.949	-0.218	.003	.001	3	5
LUNG_SCLC	RSL1D1 →	-0.726	-0.202	<.001	<.001	3	5
STOMACH	TWNK →	-0.828	-0.310	.003	.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031281 vs PYCR1 — STOMACH

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