Across TCGA pan-cancer cohorts, RNA activity of the Regulation of cyclase activity pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 54 member genes.
The strongest signal is observed in uveal melanoma (UVM), where higher Regulation of cyclase activity pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UVM and LUAD, show the opposite pattern, with higher activity associated with better survival.
UVM, LUAD, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.
Pathway-activity survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.