Biomineral tissue development

Across TCGA patient cohorts, RNA activity of the Biomineral tissue development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DCN, NEXN_S226, and OLFML3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Biomineral tissue development activity versus DCN in BRCA (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DCN →	+0.878	+0.029	<.001	<.001	3	10
LSCC	NEXN_S226 →	+0.793	+0.045	<.001	<.001	3	10
OV	OLFML3 →	+0.838	+0.035	<.001	<.001	3	10
UCEC	ARHGEF17 →	+0.437	+0.038	.001	.002	3	10
OV	PRKG1 →	+0.746	+0.051	<.001	<.001	3	10
GBM	RSU1 →	+0.403	+0.055	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031214 vs DCN — BRCA

Explore this scatter interactively →