Biomineral tissue development

Across TCGA cell cohorts, RNA activity of the Biomineral tissue development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C7orf57, POLR1B, and PLD4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Biomineral tissue development activity versus C7orf57 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C7orf57 →	+0.838	+0.345	.008	.009	3	4
BONE	POLR1B →	-0.905	-0.514	.003	.001	3	4
BLOOD_Myeloma	PLD4 →	+5.589	+0.477	<.001	<.001	3	3
BLOOD_Myeloma	PLEKHO1 →	-2.727	-0.392	.007	.006	3	3
BREAST	CYFIP2 →	-2.514	-0.632	.002	.008	3	3
BONE	SSB →	-0.831	-0.528	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031214 vs C7orf57 — UPPER_AERODIGESTIVE_TRACT

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