"Post-translational protein targeting to membrane, translocation"

Across TCGA patient cohorts, RNA activity of the "Post-translational protein targeting to membrane, translocation" pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP3K7, DNAJB1, and AKAP12, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Post-translational protein targeting to membrane, translocation" activity versus MAP3K7 in LSCC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP3K7 →	+0.123	+0.042	<.001	<.001	3	7
LSCC	DNAJB1 →	-0.476	-0.066	<.001	<.001	3	6
COAD	AKAP12 →	+0.623	+0.024	<.001	.002	3	6
GBM	PLCB1 →	+0.468	+0.053	<.001	<.001	3	6
COAD	RRM1 →	-0.402	-0.030	.001	<.001	3	5
GBM	VTA1 →	+0.334	+0.072	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031204 vs MAP3K7 — LSCC

Explore this scatter interactively →