"Post-translational protein targeting to membrane, translocation"

Across TCGA patient cohorts, RNA activity of the "Post-translational protein targeting to membrane, translocation" pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUFY2, ZNF12, and MIB1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Post-translational protein targeting to membrane, translocation" activity versus RUFY2 in BRCA (Pearson r = -0.16).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RUFY2 →	-0.326	-0.135	.001	<.001	3	6
PDAC	ZNF12 →	-0.322	-0.228	.001	.003	3	6
BRCA	MIB1 →	-0.447	-0.104	.001	.007	3	5
PDAC	ZNF326 →	-0.372	-0.360	<.001	.002	3	5
BRCA	DENND6A →	-0.368	-0.144	<.001	<.001	3	5
PDAC	NDUFAF4P3 →	-0.492	-0.290	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031204 vs RUFY2 — BRCA

Explore this scatter interactively →