"Post-translational protein targeting to membrane, translocation"

Across TCGA cell cohorts, RNA activity of the "Post-translational protein targeting to membrane, translocation" pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMED10, TMED9, and ERP44, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Post-translational protein targeting to membrane, translocation" activity versus TMED10 in BONE (Pearson r = 0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TMED10 →	+1.354	+0.405	.004	.002	3	7
BONE	TMED9 →	+1.389	+0.343	.004	.007	3	7
BONE	ERP44 →	+1.211	+0.413	.004	.001	3	7
BLOOD_Lymphoma	DNAJB11 →	+0.890	+0.148	.002	<.001	3	6
BLOOD_Leukemia	DDOST →	+0.800	+0.162	.001	.002	3	6
BLOOD_Leukemia	FNDC3B →	+1.871	+0.188	.001	.001	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031204 vs TMED10 — BONE

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