Peptide modification

Across TCGA patient cohorts, RNA activity of the Peptide modification pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LANCL2, GGT1, and LANCL3, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide modification activity versus LANCL2 in GBM (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LANCL2 →	+1.732	+0.096	<.001	<.001	3	26
STAD	GGT1 →	+1.762	+0.130	<.001	<.001	3	21
SCLC	LANCL3 →	-1.066	-0.396	.001	<.001	2	20
UVM	NIPSNAP2 →	+0.907	+0.057	<.001	<.001	3	19
ESCA	IQCE →	+0.634	+0.090	<.001	<.001	3	17
TGCT	PAM →	+1.533	+0.106	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031179 vs LANCL2 — GBM

Explore this scatter interactively →