Peptide modification

Across TCGA patient cohorts, RNA activity of the Peptide modification pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LANCL2, GTF2I, and BAZ1B, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide modification activity versus LANCL2 in GBM (Pearson r = 0.52).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	LANCL2 →	+0.824	+0.103	<.001	<.001	3	9
LSCC	GTF2I →	+0.343	+0.097	<.001	<.001	3	8
HNSC	BAZ1B →	+0.277	+0.106	.003	.002	3	6
LUAD	POLR1F →	+0.309	+0.099	.002	.002	3	6
BRCA	CAD →	+0.171	+0.063	.001	<.001	3	6
OV	SPN →	-0.729	-0.084	.002	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031179 vs LANCL2 — GBM

Explore this scatter interactively →