Peptide modification

Across TCGA cell cohorts, RNA activity of the Peptide modification pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MVK, SUMO3, and RAD23B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MVK grouped by Peptide modification-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MVK →	+0.829	+1.204	.008	.006	3	5
LUNG_NSCLC_LUSC	SUMO3 →	+0.700	+0.978	.002	.008	3	5
KIDNEY	RAD23B →	+0.687	+1.345	.002	.002	3	4
CNS	NEK7 →	+1.272	+1.026	.001	.001	3	4
CNS	MT-CO2 →	-0.800	-1.020	.001	.001	3	4
LARGE_INTESTINE	PRKAB1 →	-0.521	-0.793	.009	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MVK by Peptide modification activity — SOFT_TISSUE

Explore this box plot interactively →