Peptide modification

Across TCGA cell cohorts, RNA activity of the Peptide modification pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ENOPH1, NUP37, and HIRA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptide modification activity versus ENOPH1 in LUNG_SCLC (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ENOPH1 →	+0.640	+1.292	.006	.001	3	4
LARGE_INTESTINE	NUP37 →	-0.932	-0.324	.006	.003	3	3
LUNG_SCLC	HIRA →	+0.907	+1.312	<.001	.001	3	3
LUNG_SCLC	FGL1 →	+1.331	+1.933	.007	<.001	3	3
LUNG_SCLC	FAM222A →	+2.270	+1.521	.005	<.001	3	3
LUNG_SCLC	CXXC1 →	+0.788	+1.202	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031179 vs ENOPH1 — LUNG_SCLC

Explore this scatter interactively →