rRNA methylation

Across TCGA patient cohorts, RNA activity of the rRNA methylation pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNRIP1, ZCCHC24, and ADAMTSL2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA methylation activity versus CNRIP1 in CCRCC (Pearson r = -0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CNRIP1 →	-0.552	-0.151	<.001	<.001	3	8
BRCA	ZCCHC24 →	-0.813	-0.200	<.001	<.001	3	7
BRCA	ADAMTSL2 →	-0.872	-0.229	<.001	<.001	3	7
BRCA	PDE1A →	-0.838	-0.311	<.001	<.001	3	7
BRCA	RBMS3 →	-0.764	-0.296	<.001	<.001	3	7
BRCA	ZEB1 →	-0.821	-0.230	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031167 vs CNRIP1 — CCRCC

Explore this scatter interactively →