rRNA methylation

Across TCGA cell cohorts, RNA activity of the rRNA methylation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNB2, SFT2D2, and SSH2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GNB2 grouped by rRNA methylation-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GNB2 →	-0.577	-0.281	.001	.001	3	4
LARGE_INTESTINE	SFT2D2 →	-0.676	-0.304	.006	<.001	3	4
LARGE_INTESTINE	SSH2 →	-0.635	-0.266	.001	.009	3	4
LIVER	MAPKAPK2 →	-0.828	-0.203	.007	.004	3	4
LARGE_INTESTINE	ORMDL3 →	-0.825	-0.307	<.001	<.001	3	4
LARGE_INTESTINE	ARSD →	-1.456	-0.286	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GNB2 by rRNA methylation activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →