Developmental induction

Across TCGA patient cohorts, RNA activity of the Developmental induction pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DENND1C_S596, SEPTIN7, and U2SURP_S485, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Developmental induction activity versus DENND1C_S596 in GBM (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DENND1C_S596 →	-0.673	-0.053	<.001	.001	3	6
PDAC	SEPTIN7 →	+0.236	+0.040	<.001	.001	3	6
LUAD	U2SURP_S485 →	-0.790	-0.045	.002	.001	3	5
LUAD	ZFYVE21 →	+0.192	+0.041	.001	<.001	3	5
LSCC	CSDE1_S514 →	-0.799	-0.039	<.001	.003	3	5
GBM	NUF2_S247 →	-0.674	-0.055	.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031128 vs DENND1C_S596 — GBM

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