Developmental induction

Across TCGA patient cohorts, RNA activity of the Developmental induction pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAJ36, DOK3, and SCIMP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Developmental induction activity versus TRAJ36 in OV (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TRAJ36 →	-0.445	-0.904	<.001	.009	3	4
GBM	DOK3 →	-0.639	-0.603	<.001	<.001	3	4
CCRCC	SCIMP →	-0.378	-0.731	.008	.001	3	4
LUAD	COX10-AS1 →	+0.194	+0.382	.005	.003	3	4
BRCA	SLAMF6 →	-0.821	-0.669	.002	<.001	3	4
BRCA	LILRB3 →	-0.761	-0.690	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031128 vs TRAJ36 — OV

Explore this scatter interactively →