Developmental induction

Across TCGA cell cohorts, RNA activity of the Developmental induction pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM114A1, FSTL3, and TOE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM114A1 grouped by Developmental induction-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	FAM114A1 →	-1.446	-0.762	.002	.006	3	4
LUNG_NSCLC_LUSC	FSTL3 →	-2.099	-0.756	.003	.006	3	4
LARGE_INTESTINE	TOE1 →	+0.492	+0.489	<.001	.002	3	4
STOMACH	HIBADH →	-0.847	-0.300	.008	.002	3	3
LUNG_NSCLC_LUSC	TRIM21 →	-1.033	-0.739	.001	.008	3	3
LUNG_NSCLC_LUSC	PXDC1 →	-1.948	-1.081	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM114A1 by Developmental induction activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →