Developmental induction

Across TCGA cell cohorts, RNA activity of the Developmental induction pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DYRK1B, POLD2, and UBE3D, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Developmental induction activity versus DYRK1B in SKIN (Pearson r = -0.75).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DYRK1B →	-2.325	-0.431	.003	.002	3	1
SKIN	POLD2 →	+0.839	+0.459	.003	<.001	3	1
SKIN	UBE3D →	+0.826	+0.594	.002	.009	3	1
SKIN	TAF12 →	+0.480	+0.594	.003	.009	3	1
SKIN	STRIP2 →	+1.973	+0.594	.002	.009	3	1
SKIN	ARHGEF11 →	+1.726	+0.461	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031128 vs DYRK1B — SKIN

Explore this scatter interactively →