rRNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the rRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUFT1, SCLY, and CAPN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, rRNA 3'-end processing activity versus TUFT1 in CNS (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TUFT1 →	-1.318	-0.216	.005	.003	2	6
OVARY	SCLY →	+1.101	+0.237	.001	<.001	3	5
URINARY_TRACT	CAPN1 →	-2.284	-0.346	<.001	.006	3	5
BLOOD_Lymphoma	TMEM87B →	-0.710	-0.146	<.001	.008	3	5
SOFT_TISSUE	TSPAN15 →	-2.146	-0.233	.001	<.001	3	5
LIVER	RPAIN →	+1.048	+0.272	.008	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031125 vs TUFT1 — CNS

Explore this scatter interactively →