mRNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the mRNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STRBP, UPF3B, and CAMK2N1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, mRNA 3'-end processing activity versus STRBP in BLOOD_Lymphoma (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	STRBP →	+1.414	+0.206	.004	.001	3	6
LUNG_SCLC	UPF3B →	+0.711	+0.187	<.001	<.001	3	5
OVARY	CAMK2N1 →	-3.142	-0.245	<.001	.004	2	6
CNS	SLC22A4 →	-1.789	-0.200	<.001	.005	3	5
BLOOD_Lymphoma	LGALS3 →	-2.255	-0.143	.009	.009	2	6
BLOOD_Lymphoma	CDK4 →	+0.805	+0.174	.005	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031124 vs STRBP — BLOOD_Lymphoma

Explore this scatter interactively →