RNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the RNA 3'-end processing pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GATAD2B, HCFC1, and RPRD2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA 3'-end processing activity versus GATAD2B in LSCC (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GATAD2B →	+0.315	+0.041	.002	.001	3	6
HNSC	HCFC1 →	+0.155	+0.056	.005	.006	3	6
LSCC	RPRD2 →	+0.319	+0.038	<.001	.001	2	6
BRCA	STIM1 →	-0.385	-0.028	<.001	<.001	3	5
BRCA	TBL2 →	-0.258	-0.019	.001	.001	3	5
HNSC	SMC3 →	+0.201	+0.065	.008	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031123 vs GATAD2B — LSCC

Explore this scatter interactively →