RNA 3'-end processing

Across TCGA patient cohorts, RNA activity of the RNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TCEAL7, PLXDC2, and DIPK2B, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, RNA 3'-end processing activity versus TCEAL7 in BRCA (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TCEAL7 →	-0.703	-0.167	<.001	<.001	3	8
COAD	PLXDC2 →	-0.993	-0.277	<.001	<.001	3	7
BRCA	DIPK2B →	-0.782	-0.196	<.001	<.001	3	7
BRCA	ZCCHC24 →	-1.172	-0.241	<.001	<.001	3	7
OV	NTM →	-1.129	-0.184	<.001	<.001	3	7
BRCA	DACT3 →	-0.613	-0.147	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031123 vs TCEAL7 — BRCA

Explore this scatter interactively →