RNA 3'-end processing

Across TCGA cell cohorts, RNA activity of the RNA 3'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBOX5, RTN3, and IFTAP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBOX5 grouped by RNA 3'-end processing-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	UBOX5 →	-0.544	-0.169	<.001	<.001	3	5
LUNG_SCLC	RTN3 →	-0.987	-0.170	.005	.008	3	4
LUNG_SCLC	IFTAP →	+1.760	+0.141	<.001	.004	3	4
LUNG_SCLC	FAM114A2 →	+1.258	+0.220	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PIGK →	-0.652	-0.132	.003	.001	3	4
LUNG_NSCLC_LUSC	HLA-A →	-1.660	-0.140	.007	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBOX5 by RNA 3'-end processing activity — LUNG_SCLC

Explore this box plot interactively →