Cytoplasmic microtubule organization

Across TCGA patient cohorts, RNA activity of the Cytoplasmic microtubule organization pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, RPL26, and RPL3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoplasmic microtubule organization activity versus RPL5 in OV (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RPL5 →	-0.215	-0.050	<.001	<.001	3	7
GBM	RPL26 →	-0.809	-0.076	.001	<.001	3	6
GBM	RPL3 →	-0.284	-0.041	.001	<.001	3	6
GBM	RPS8 →	-0.296	-0.047	.001	<.001	3	6
GBM	RPL7 →	-0.398	-0.048	<.001	<.001	3	6
OV	RPL21 →	-0.265	-0.035	.006	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031122 vs RPL5 — OV

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