Cytoplasmic microtubule organization

Across TCGA cell cohorts, RNA activity of the Cytoplasmic microtubule organization pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM67, ZMAT1, and RCOR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoplasmic microtubule organization activity versus TMEM67 in URINARY_TRACT (Pearson r = -0.76).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TMEM67 →	-1.066	-0.186	<.001	<.001	3	5
URINARY_TRACT	ZMAT1 →	-1.232	-0.231	.003	.005	3	5
CNS	RCOR2 →	-1.170	-0.148	.005	.009	3	5
OESOPHAGUS	ZNF124 →	-0.891	-0.220	<.001	.001	3	4
LIVER	MRPL16 →	-0.884	-0.229	.002	.001	3	4
LIVER	MAP4K2 →	-0.997	-0.230	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031122 vs TMEM67 — URINARY_TRACT

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