tRNA pseudouridine synthesis

Across TCGA patient cohorts, RNA activity of the tRNA pseudouridine synthesis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAPK14, ATAD3A, and AACS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA pseudouridine synthesis activity versus MAPK14 in GBM (Pearson r = 0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MAPK14 →	+0.220	+0.037	.008	.003	3	5
PDAC	ATAD3A →	+0.379	+0.039	<.001	.001	3	5
PDAC	AACS →	+0.398	+0.036	.002	.004	3	5
PDAC	RER1 →	+0.300	+0.040	.003	.001	3	4
LUAD	RRP8 →	+0.288	+0.047	<.001	<.001	3	4
PDAC	TMCO1 →	+0.567	+0.045	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031119 vs MAPK14 — GBM

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