tRNA pseudouridine synthesis

Across TCGA patient cohorts, RNA activity of the tRNA pseudouridine synthesis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BID, MRPS26, and SNRPF, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA pseudouridine synthesis activity versus BID in OV (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BID →	+0.487	+0.668	.003	.003	3	3
LSCC	MRPS26 →	+0.405	+0.128	.003	.002	3	3
PDAC	SNRPF →	+0.270	+0.500	<.001	<.001	3	3
PDAC	DGAT2 →	+0.586	+0.552	<.001	.001	3	3
LSCC	SNRPB →	+0.427	+0.160	<.001	<.001	3	3
LSCC	KLRC1 →	-0.505	-0.113	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031119 vs BID — OV

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