tRNA pseudouridine synthesis

Across TCGA cell cohorts, RNA activity of the tRNA pseudouridine synthesis pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PUS10, PUS7, and PUS1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PUS10 grouped by tRNA pseudouridine synthesis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PUS10 →	-0.390	-1.385	.006	.008	2	10
LARGE_INTESTINE	PUS7 →	-0.233	-2.018	<.001	<.001	3	7
CNS	PUS1 →	-0.250	-1.314	<.001	<.001	3	7
LARGE_INTESTINE	HECTD1 →	-0.235	-1.473	.003	.001	3	5
KIDNEY	RPUSD4 →	-0.206	-1.511	.004	.004	1	7
SKIN	GBE1 →	+0.121	+0.891	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PUS10 by tRNA pseudouridine synthesis activity — PANCREAS

Explore this box plot interactively →