Regulation of microtubule depolymerization

Across TCGA cell cohorts, RNA activity of the Regulation of microtubule depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1orf216, IL6ST, and RGS9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, C1orf216 grouped by Regulation of microtubule depolymerization-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1orf216 →	-0.771	-0.235	.008	.005	3	4
STOMACH	IL6ST →	-1.373	-0.231	.003	.009	3	4
BREAST	RGS9 →	-0.747	-0.139	.003	.008	3	4
PANCREAS	DGKQ →	-0.787	-0.331	.001	.002	3	3
PANCREAS	PHF6 →	-0.623	-0.239	.001	.006	3	3
BONE	IFT57 →	-0.992	-0.340	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C1orf216 by Regulation of microtubule depolymerization activity — LARGE_INTESTINE

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