Regulation of microtubule depolymerization

Across TCGA cell cohorts, RNA activity of the Regulation of microtubule depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ARHGEF2, FYN, and AKT3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule depolymerization activity versus ARHGEF2 in LUNG_NSCLC_LUSC (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	ARHGEF2 →	+1.562	+1.398	.003	<.001	3	5
LUNG_SCLC	FYN →	+1.515	+0.466	.001	.009	3	5
OVARY	AKT3 →	+2.088	+0.979	.002	<.001	3	4
URINARY_TRACT	PRR5 →	-1.608	-1.172	.009	<.001	3	4
LIVER	IDE →	-0.334	-1.443	.009	.002	3	4
BLOOD_Leukemia	GDI1 →	+0.929	+0.529	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031114 vs ARHGEF2 — LUNG_NSCLC_LUSC

Explore this scatter interactively →