Regulation of microtubule polymerization

Across TCGA patient cohorts, RNA activity of the Regulation of microtubule polymerization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL23A, RPL5, and KIF1A_S1370, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule polymerization activity versus RPL23A in GBM (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL23A →	-0.265	-0.044	<.001	<.001	3	7
GBM	RPL5 →	-0.168	-0.052	<.001	<.001	3	7
LSCC	KIF1A_S1370 →	+2.490	+0.042	<.001	.001	3	6
BRCA	RPL7 →	-0.322	-0.022	<.001	.006	3	6
BRCA	RPL4 →	-0.405	-0.021	<.001	.006	3	6
GBM	RRBP1 →	-0.513	-0.070	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031113 vs RPL23A — GBM

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