Regulation of microtubule polymerization

Across TCGA patient cohorts, RNA activity of the Regulation of microtubule polymerization pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPYSL3, MAP1B, and CHAMP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule polymerization activity versus DPYSL3 in CCRCC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	DPYSL3 →	+0.761	+0.860	.007	.006	3	3
CCRCC	MAP1B →	+1.084	+1.105	<.001	<.001	3	3
CCRCC	CHAMP1 →	-0.319	-0.805	.001	.001	3	3
CCRCC	MIR221 →	+0.720	+0.725	.008	.008	3	3
CCRCC	SFTA1P →	+0.775	+0.899	<.001	.004	3	3
CCRCC	ITGB3 →	+0.911	+0.950	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031113 vs DPYSL3 — CCRCC

Explore this scatter interactively →