Regulation of microtubule polymerization

Across TCGA cell cohorts, RNA activity of the Regulation of microtubule polymerization pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KHK, DHRSX, and ALKBH3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KHK grouped by Regulation of microtubule polymerization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KHK →	+0.164	+0.217	.001	.004	2	6
BLOOD_Myeloma	DHRSX →	+0.367	+0.547	.008	.002	3	5
LUNG_NSCLC_LUAD	ALKBH3 →	+0.143	+0.215	.003	.005	3	4
SOFT_TISSUE	EIF3J →	-0.360	-0.335	.003	.003	3	4
KIDNEY	PPARA →	+0.324	+0.249	.008	.002	3	4
BREAST	PTPMT1 →	+0.176	+0.175	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KHK by Regulation of microtubule polymerization activity — BLOOD_Leukemia

Explore this box plot interactively →