Regulation of microtubule polymerization

Across TCGA cell cohorts, RNA activity of the Regulation of microtubule polymerization pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRAT2, ARF4, and ZBTB16, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FRAT2 grouped by Regulation of microtubule polymerization-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FRAT2 →	-0.376	-0.256	.004	.005	3	3
OVARY	ARF4 →	+0.455	+0.880	.003	.004	3	3
BREAST	ZBTB16 →	+0.187	+0.845	.004	<.001	3	3
BREAST	MKRN1 →	+0.158	+0.678	.003	.008	3	3
PANCREAS	NR1H2 →	+0.213	+0.179	<.001	<.001	3	3
STOMACH	BLM →	+0.240	+0.950	.008	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FRAT2 by Regulation of microtubule polymerization activity — CNS

Explore this box plot interactively →