Regulation of microtubule polymerization

Across TCGA cell cohorts, RNA activity of the Regulation of microtubule polymerization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUOX, MTUS1, and SPPL2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule polymerization activity versus SUOX in BLOOD_Leukemia (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SUOX →	-1.065	-0.138	.005	.001	3	4
LARGE_INTESTINE	MTUS1 →	-1.423	-0.581	.005	.008	3	4
BLOOD_Lymphoma	SPPL2A →	-1.156	-0.655	.001	.002	3	3
STOMACH	AQP3 →	-2.686	-0.979	.003	.005	3	3
BREAST	MYCL →	-0.924	-0.675	.001	.001	3	3
BREAST	C3orf18 →	+1.162	+0.773	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031113 vs SUOX — BLOOD_Leukemia

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