Positive regulation of microtubule polymerization or depolymerization

Across TCGA cell cohorts, RNA activity of the Positive regulation of microtubule polymerization or depolymerization pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC1, DCTN1, and RAPGEF1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAC1 grouped by Positive regulation of microtubule polymerization or depolymerization-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	RAC1 →	-0.333	-0.231	.001	.004	2	8
SOFT_TISSUE	DCTN1 →	-0.474	-0.341	<.001	.003	3	6
OVARY	RAPGEF1 →	-0.314	-0.335	.001	<.001	3	5
BLOOD_Leukemia	ANKRD62 →	+0.275	+0.452	.004	.001	3	4
LIVER	PDE1C →	-0.336	-0.343	.005	.002	3	4
BLOOD_Myeloma	AJUBA →	+0.236	+0.313	.004	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAC1 by Positive regulation of microtubule polymerization or depolymerization activity — OESOPHAGUS

Explore this box plot interactively →