Negative regulation of microtubule polymerization or depolymerization

Across TCGA patient cohorts, RNA activity of the Negative regulation of microtubule polymerization or depolymerization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CACNA2D1, HDGFL3, and COL4A2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of microtubule polymerization or depolymerization activity versus CACNA2D1 in GBM (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CACNA2D1 →	+0.704	+0.074	<.001	<.001	3	8
GBM	HDGFL3 →	+0.419	+0.054	<.001	<.001	3	8
COAD	COL4A2 →	+0.359	+0.024	.001	.005	3	7
UCEC	MAP1B →	+0.621	+0.051	.008	.005	2	8
OV	RPL5 →	-0.161	-0.057	.005	<.001	3	7
OV	LAMA4 →	+0.399	+0.048	.002	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031111 vs CACNA2D1 — GBM

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