Negative regulation of microtubule polymerization or depolymerization

Across TCGA cell cohorts, RNA activity of the Negative regulation of microtubule polymerization or depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM158, MYL6B, and MPP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TMEM158 grouped by Negative regulation of microtubule polymerization or depolymerization-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TMEM158 →	-2.484	-0.282	.006	.005	3	5
URINARY_TRACT	MYL6B →	-0.951	-0.282	.008	.004	3	4
BREAST	MPP1 →	-1.720	-0.229	<.001	<.001	3	4
BREAST	FOSL1 →	-2.848	-0.210	.001	.002	3	4
BREAST	MT1X →	-1.615	-0.193	.002	<.001	3	4
BLOOD_Lymphoma	ZEB2 →	-3.293	-0.530	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TMEM158 by Negative regulation of microtubule polymerization or depolymerization activity — BONE

Explore this box plot interactively →