Negative regulation of microtubule polymerization or depolymerization

Across TCGA cell cohorts, RNA activity of the Negative regulation of microtubule polymerization or depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLEKHJ1, ECSIT, and LSM7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of microtubule polymerization or depolymerization activity versus PLEKHJ1 in LUNG_SCLC (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PLEKHJ1 →	+0.867	+0.269	<.001	.001	3	4
LUNG_SCLC	ECSIT →	+0.622	+0.278	.004	.002	3	4
LUNG_SCLC	LSM7 →	+0.517	+0.271	<.001	<.001	3	4
LUNG_SCLC	FRS3 →	+0.621	+0.259	.009	.003	3	4
LUNG_SCLC	PSD3 →	+1.483	+0.287	.002	.002	3	4
LUNG_NSCLC_LUSC	ZSWIM8 →	+1.427	+0.380	.003	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0031111 vs PLEKHJ1 — LUNG_SCLC

Explore this scatter interactively →